# KU Leuven

Piet Herdewijn's group published structural work on a Thermococcus kodakarensis DNA polymerase (KOD-H4) engineered for HNA (hexose nucleic acid) reverse transcription, providing the first structural insight into how a DNA polymerase processes a xeno-nucleic acid backbone.

Source: https://cn.bioecon.ru/companies/ku-leuven/
Updated: 2026-07-05

- 国家: Belgium

## 可核验事实

| 事实 | 数值 | 来源 |
| --- | --- | --- |
| 隶属机构 | 比利时鲁汶大学Rega研究所药物化学系 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11724289/, https://www.kuleuven.be/wieiswie/en/person/00010383 |
| 研究方向 | 药物化学、药物发现（病毒学、细菌学、免疫学、神经科学）、合成生物学、核酸化学、人工遗传系统及聚合酶定向进化 | https://research.kuleuven.be/portal/en/user/U0010383, https://ullapharmsci.org/wp-content/uploads/ULLA-Research-Portfolios-latest.pdf, https://www.michaeljfox.org/researcher/piet-herdewijn-phd |
| 科研资助 | 用于XNA开发的ERC资助；德国研究基金会资助（MA2288/22-1）；医学研究理事会资助（MC_U105178804） | https://doi.org/10.1093/nar/gkae1156, https://gbiomed.kuleuven.be/english/research/50000715/spotlightfolder/erc_PH, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0351418, https://pmc.ncbi.nlm.nih.gov/articles/PMC11724289/ |
| 员工人数 | 约20名博士生及15名博士后（截至2019年） | https://ullapharmsci.org/wp-content/uploads/ULLA-Research-Portfolios-latest.pdf |
| 主要研究人员 | Piet Herdewijn、Mikhail Abramov、Frédérick Coosemans | https://doi.org/10.1093/nar/gkae1156, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0351418, https://pmc.ncbi.nlm.nih.gov/articles/PMC11724289/ |

独立来源: doi.org, journals.plos.org, michaeljfox.org, pmc.ncbi.nlm.nih.gov, ullapharmsci.org

## 技术

- [异种生物学与扩展遗传字母表（XNA）](https://cn.bioecon.ru/technology/xenobiology-expanded-genetic-alphabet/)